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Genetic predisposition to early mycosis fungoides: investigating genetic polymorphisms in tissue-resident memory
Nour Almaani1, Fatima Farhan2, Salsabiela Bani Hamad1
1Department of Dermatology, The University of Jordan, Amman, Jordan.
Objectives:
Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma; it arises from tissue-resident memory T-cells (TRM). In the present study, we investigated potential functional genetic variations that may predispose MF development.
Methods:
A case-control study was conducted using whole-exome sequencing, with a focus on genes that are essential to TRM function.
Results:
We included 21 patients and 19 healthy subjects in the study. Single nucleotide polymorphisms in the following genes were significantly more common in patients than in healthy subjects: GZMB, HLA-DRB1, CD103, and NOTCH1. Moreover, the number of patients carrying single nucleotide polymorphisms in LAG3, NR4A2, and CD26L was significantly greater in the patient group than in the control group.
Conclusions:
The presence of genetic variations in one or more TRM functional gene may predispose patients to develop MF. Further studies involving a larger patient population and a comparative analysis of protein expression will be necessary to validate these findings.
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