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Hepatic Drug Excretion: Enterohepatic Cycling

Hepatic Drug Excretion: Enterohepatic Cycling

Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...

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Related Experiment Video

Updated: Jun 29, 2025

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

Published on: May 16, 2015

Hepatic Encephalopathy

¹David Geffen School of Medicine at UCLA, Departments of Medicine and Surgery, Suite 700, 100 Medical Plaza, Los Angeles, CA 90095, USA.

Clinics in Liver Disease

|March 28, 2024

Summary

No abstract available in PubMed .

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