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The Association Between Lean-to-Fat Mass Ratio and Cardiometabolic Abnormalities: An Analytical Cross-Sectional Study

Jamee Guerra Valencia1, Antonio Castillo-Paredes2, Carolina Gibaja-Arce3

  • 1Facultad de Ciencias de la Salud, Universidad Privada del Norte, Lima 15314, Peru.

Journal of Clinical Medicine Research
|March 29, 2024
PubMed

Insights

Higher lean-to-fat mass ratio (LFMR) is linked to fewer cardiometabolic abnormalities (CAs) in Peruvian adults. This study highlights LFMR

Area of Science:

  • Public Health
  • Human Physiology
  • Epidemiology

Background:

  • Cardiovascular diseases (CVDs) pose a significant global health challenge, particularly in Latin America.
  • Cardiometabolic abnormalities (CAs), including lipid profile, glucose, and blood pressure issues, are key contributors to CVD.
  • Previous research in Latin America has focused on traditional obesity measures, neglecting body composition like lean-to-fat mass ratio (LFMR).

Purpose of the Study:

  • To investigate the association between the lean-to-fat mass ratio (LFMR) and cardiometabolic abnormalities (CAs).
  • To analyze body composition's role in cardiometabolic health within the adult Peruvian population.

Main Methods:

  • An analytical cross-sectional study utilized secondary data from the PERU MIGRANT study (2007).
  • Cardiometabolic abnormalities (CAs) were defined as having ≥ 2 out of six metabolic risk factors.
  • A generalized linear model analyzed the association between LFMR tertiles and CAs, calculating adjusted prevalence ratios (aPRs).

Main Results:

  • The study included 959 adults aged 30+; 50.9% had CAs.
  • A higher LFMR showed a significant inverse association with CAs in most female age groups and younger males (30-44 years).
  • Associations varied by sex and age, with no significant link found between LFMR and CAs in older males (45-59 years).

Conclusions:

  • The lean-to-fat mass ratio (LFMR) is negatively associated with cardiometabolic abnormalities (CAs) in the Peruvian adult population.
  • LFMR is a relevant indicator for understanding and addressing cardiometabolic health disparities.
Abstract

Keywords:
Body compositionCardiometabolic risk factorsFat massLatin AmericaLean massMetabolic syndrome

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