Magnetic Particle Spray Mass Spectrometry.

Area of Science:

• Analytical Chemistry
• Mass Spectrometry
• Green Chemistry

Background:

• Traditional mass spectrometry often requires extensive sample preparation, leading to increased solvent consumption and waste.
• Developing efficient and environmentally friendly analytical techniques is crucial for sustainable scientific practices.

Purpose of the Study:

• To introduce and demonstrate the novel Magnetic Particle Spray Mass Spectrometry (MPS-MS) technique.
• To showcase MPS-MS as a green analytical method with high sensitivity and selectivity.
• To validate MPS-MS for the quantification of specific analytes in complex biological matrices.

Main Methods:

• Utilized magnetic sorbent particles for analyte extraction from liquid samples.
• Employed a magnetic probe for particle manipulation at the mass spectrometer entrance.
• Applied a solvent and high voltage to induce desorption, ionization, and analysis via mass spectrometry.

Main Results:

• Achieved excellent sensitivity and selectivity with minimal sample (100 μL) and solvent (34 μL) consumption.
• Successfully quantified eight pharmaceutical compounds in human plasma samples.
• Obtained limits of quantification at 10 μg L⁻¹, correlation coefficients > 0.98, and low limits of detection.

Conclusions:

• Magnetic Particle Spray Mass Spectrometry (MPS-MS) represents a significant advancement in combining sample preparation with ambient ionization.
• The technique aligns with green chemistry principles, offering a sustainable alternative for various analytical applications.
• MPS-MS demonstrates broad potential for analyzing diverse analytes in different sample types with optimized configurations.