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Microfluidic point-of-care testing for the detection of Bordetella pertussis: A mini-review

Çiğdem Yılmaz Çolak1

  • 1TUBITAK, Marmara Research Center, Kocaeli, Turkiye.

Diagnostic Microbiology and Infectious Disease
|March 29, 2024
PubMed

Insights

Bordetella pertussis causes reemerging pertussis. Microfluidic technology offers rapid, accurate point-of-care testing (POCT) for improved diagnosis and control of this contagious respiratory disease.

Area of Science:

  • Microbiology
  • Medical Diagnostics
  • Biotechnology

Background:

  • Bordetella pertussis causes pertussis, a highly contagious respiratory illness.
  • Pertussis is reemerging despite high vaccination rates, requiring better diagnostic strategies.
  • Current diagnostic methods for pertussis have limitations in sensitivity, specificity, and speed.

Purpose of the Study:

  • To discuss current pertussis diagnostic tools and their limitations.
  • To highlight microfluidic approaches as a promising alternative for pertussis diagnosis.

Main Methods:

  • Review of existing literature on pertussis diagnostics.
  • Exploration of microfluidic technology principles and applications in infectious disease diagnosis.

Main Results:

  • Current diagnostic methods for pertussis face challenges.
  • Microfluidic technology demonstrates potential for rapid, sensitive, and specific pertussis detection.
  • Microfluidics enables point-of-care testing (POCT), crucial for outbreak management.

Conclusions:

  • Microfluidic technology presents a significant advancement for diagnosing pertussis.
  • This technology can enhance the speed, accuracy, and accessibility of pertussis diagnosis.
  • Microfluidics offers a pathway to improved identification, prevention, and control strategies for pertussis.
Keywords:
Bordetella pertussisDiagnosisMicrofluidicsPoint-of-care testingWhooping cough

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