The Use of Low-Dose Dopamine in the Neonatal Intensive Care Unit

Dopamine has been used for half a century in adult and pediatric patients for the treatment of hypotension, as well as for the theoretical prevention of acute kidney injury (AKI). Although activation of renal dopamine receptors leads to increased urine output, there is no evidence that low-dose dopamine reduces the incidence of AKI, need for dialysis, or death. Dopamine administration is also associated with multiple adverse effects, particularly in preterm infants. Despite the lack of evidence for its use, as well as the known adverse effects of dopamine, many neonatologists still use low-dose dopamine to prevent or treat AKI in neonates. In this review, we provide a summary of our current medical knowledge about the use of low-dose dopamine in the neonatal population.