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Updated: Jun 29, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Rh(III)-Catalyzed Controlled Ortho-Amidation of Arylamides with Dioxazolones Using Weakly Coordinating Native Primary
Saksham Mishra1, Anjali Aghi1, Amit Kumar1
1Department of Chemistry, Indian Institute of Technology, Bihta, Patna 801106, Bihar, India.
Abstract:
Herein, we report a controlled introduction of an amide unit at the ortho-position of an electron-deficient arylamide system without affording any cyclized products using user-friendly dioxazolone as an amidating reagent in the presence of a Rh(III)-catalyst. This is the first report where native primary amide has been utilized as a weakly coordinating group for site-selective C-N bond formation reaction. The developed protocol works under external auxiliary-free conditions with a wide substrate scope.
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