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Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
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Intestinal microbiota and biliary system diseases.
Hua Wang1, Junfeng Gong2, Jingyi Chen3
1Department of Health, The Chinese People's Armed Police Forces Anhui Provincial Corps Hospital, Hefei, China.
Frontiers in Cellular and Infection Microbiology
|April 1, 2024
Summary
Changes in gut bacteria are linked to biliary diseases like gallstones and cancer. This study highlights specific bacterial shifts, offering potential biomarkers for early diagnosis and new treatment directions for these growing health concerns.
Area of Science:
- Gastroenterology
- Microbiology
- Oncology
Background:
- Biliary system diseases are increasing globally, posing a significant health burden.
- The exact causes and mechanisms of these diseases remain largely unknown.
- Intestinal microbiota plays a role in bile duct lipid metabolism, influencing biliary health.
Purpose of the Study:
- To systematically review and compare changes in intestinal microbiota across various biliary diseases.
- To identify potential microbial biomarkers for early diagnosis of biliary conditions.
- To explore novel therapeutic strategies targeting the gut microbiome for biliary diseases.
Main Methods:
- Systematic literature review of studies up to November 2023.
- Searched databases: PubMed, Embase, and Web of Science.
- Focused on intestinal microbiota in gallstones (GS), non-calculous biliary inflammation, and biliary tract cancer (BTC).
Main Results:
- Decreased abundance of Faecalibacterium genus observed in GS, primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and BTC.
- Increased abundance of Veillonella, Lactobacillus, Streptococcus, and Enterococcus genera in PSC, PBC, and BTC.
- Variable changes in Clostridium genus abundance across different biliary diseases (reduced in GS, PBC, BTC; increased in PSC).
Conclusions:
- Significant alterations in intestinal microbiota composition are associated with various biliary diseases.
- Specific bacterial genera show potential as biomarkers for early detection of biliary system diseases.
- Understanding these microbial shifts offers new avenues for developing targeted therapies for biliary conditions.
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