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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Updated: Jun 29, 2025

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
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A Practical Algorithm Integrating Skin Care With Nonenergy and Injectable Dermatologic Procedures to Improve Patient

Edward Lain, Anneke Andriessen, Valeria Barreto Campos

    Journal of Drugs in Dermatology : JDD
    |April 2, 2024
    PubMed
    Summary
    This summary is machine-generated.

    A new algorithm provides guidelines for skin care supporting facial antiaging treatments. This approach aims to enhance healing, reduce recovery time, and improve patient comfort and results from nonenergy and injectable procedures.

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    Apparatus for Harvesting Tissue Microcolumns
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    Area of Science:

    • Dermatology
    • Aesthetic Medicine
    • Cosmetic Science

    Background:

    • Facial antiaging treatments are increasingly popular, with nonenergy and injectable procedures being the most rapidly growing.
    • Current standards for pre-, during-, and post-treatment skin care are lacking.
    • A supportive skin care algorithm is needed to optimize healing, minimize downtime, and enhance patient experience.

    Purpose of the Study:

    • To develop a consensus-based algorithm for supportive skin care in facial antiaging nonenergy and injectable treatments.
    • To provide evidence-based recommendations for pre-, during-, and post-procedure skin management.
    • To improve treatment outcomes, patient comfort, and overall satisfaction.

    Main Methods:

    • A modified Delphi method was employed by a panel of 7 global physicians.
    • Consensus was reached on an algorithm integrating best available evidence with clinical experience.
    • The algorithm addresses pre-treatment, treatment/ongoing, post-procedure, and follow-up care phases.

    Main Results:

    • The algorithm includes a pre-treatment phase (2-4 weeks prior), day-of-treatment care, immediate post-procedure care (0-7 days), and follow-up (1-4 weeks).
    • Recommendations include broad-spectrum sunscreen (SPF 30+) and protective measures against sun exposure.
    • For dyschromia concerns, especially in pigmented skin, clinicians may recommend gentle cleansers, moisturizers with vitamins C & E, retinoids, niacinamide, and other agents like azelaic acid or tranexamic acid.

    Conclusions:

    • Integrating nonenergy/injectable procedures with optimized skin care regimens can enhance outcomes and patient satisfaction.
    • Topical antioxidants and free radical scavengers can mitigate photodamage.
    • These topical agents may serve as a safe alternative to hydroquinone for managing skin concerns.