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Updated: Jun 29, 2025

Small RNA Transfection in Primary Human Th17 Cells by Next Generation Electroporation
Published on: April 13, 2017
Friend or Foe - Tc17 cell generation and current evidence for their importance in human disease
Anna Veronika Hipp1, Bertram Bengsch1, Anna-Maria Globig1
1Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany.
Abstract:
The term Tc17 cells refers to interleukin 17 (IL-17)-producing CD8+ T cells. While IL-17 is an important mediator of mucosal defense, it is also centrally involved in driving the inflammatory response in immune-mediated diseases, such as psoriasis, multiple sclerosis, and inflammatory bowel disease. In this review, we aim to gather the current knowledge on the phenotypic and transcriptional profile, the in vitro and in vivo generation of Tc17 cells, and the evidence pointing towards a relevant role of Tc17 cells in human diseases such as infectious diseases, cancer, and immune-mediated diseases.
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