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The novel HLA-A*36:14 allele characterised by two different sequencing-based typing techniques
Adèle Dhuyser1,2, Michaël Pérès1, Sandra Clément1
1HLA and Histocompatibility Laboratory, CHRU de Nancy, Vandœuvre-lès-Nancy, France.
A new human leukocyte antigen (HLA) allele, HLA-A*36:14, has been identified. It differs from the known HLA-A*36:01:01:01 allele by a single nucleotide change in exon 4.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- The human leukocyte antigen (HLA) system plays a critical role in immune response.
- Polymorphisms within HLA genes contribute to diverse immune capabilities and disease susceptibility.
Purpose of the Study:
- To characterize a newly discovered HLA allele, designated HLA-A*36:14.
- To detail the molecular differences between this novel allele and a known reference allele.
Main Methods:
- High-resolution HLA typing was performed.
- Sequence analysis was conducted to identify nucleotide variations.
Main Results:
- A novel HLA allele, HLA-A*36:14, was identified.
- This allele differs from HLA-A*36:01:01:01 by a single non-synonymous nucleotide substitution located in exon 4.
Conclusions:
- The identification of HLA-A*36:14 expands the known HLA allele repertoire.
- This finding contributes to a deeper understanding of HLA polymorphism and its implications for immunogenetics research.
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