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The Virtual Child
Richard J Gilbertson1,2, Sam Behjati3,4,5, Anna-Lisa Böttcher6,7
1CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Cancer Discovery
|April 4, 2024
Summary
Researchers are developing the first Virtual Child, a computer model simulating human development and cancer at the cellular level. This innovative tool aims to accelerate the discovery of effective pediatric cancer treatments, ultimately saving children's lives.
Area of Science:
- Computational biology
- Developmental biology
- Pediatric oncology
Background:
- Childhood cancer remains a significant health challenge.
- Current treatment development is lengthy and costly.
- Understanding normal and cancerous human development is crucial.
Purpose of the Study:
- To create the world's first Virtual Child, a comprehensive computer model of human development.
- To simulate cancerous growth within the Virtual Child model.
- To utilize the model for extensive virtual clinical trials to identify novel pediatric cancer therapies.
Main Methods:
- Developing a cell-level computational model of human development.
- Integrating mechanisms of cancerous development into the model.
- Conducting in silico clinical trials on the Virtual Child to test treatment efficacy.
Main Results:
- The Virtual Child model is under development, representing normal and cancerous human development.
- The model will enable simulation of cancer progression and response to interventions.
- Virtual trials will identify, predict, and prioritize potential new treatments.
Conclusions:
- The Virtual Child represents a paradigm shift in pediatric cancer research.
- This approach promises to accelerate the development of life-saving treatments.
- The ultimate goal is to eliminate childhood cancer mortality.
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