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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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Light-triggered AND logic tetrapeptide dynamic covalent assembly.

Yuhua Tang1, Liang Gao2, Jinbo Fei3

  • 1College of Materials Science and Engineering, Beijing University of Technology, Beijing 100124, China.

Colloids and Surfaces. B, Biointerfaces
|April 4, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed a light-triggered method for assembling short peptides using dynamic covalent chemistry. This novel approach enables precise control over molecular assembly for potential bioapplications.

Keywords:
DisulfideDynamic covalent bondsMolecular assemblyPeptideStimuli-response

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Area of Science:

  • Biochemistry
  • Materials Science
  • Chemical Biology

Background:

  • Dynamic covalent chemistry offers responsive and reversible molecular assembly.
  • Controlling peptide assembly with external stimuli like light is crucial for advanced biomaterials.
  • Cysteine-mediated disulfide bond formation is a key reaction in biological systems and materials science.

Purpose of the Study:

  • To demonstrate light-triggered AND logic dynamic covalent assembly of a linear tetrapeptide.
  • To utilize a photobase generator for light-mediated pH regulation and thiol oxidation.
  • To explore the reversible aggregation and disaggregation of peptides via disulfide bonds.

Main Methods:

  • Synthesis of a linear tetrapeptide with terminal cysteine residues.
  • Introduction of a photobase generator for light-induced pH changes.
  • Oxidative polymerization of thiols to form disulfide bonds under light irradiation.
  • Comparative study with a control peptide lacking dual cysteine residues.

Main Results:

  • Achieved light-triggered AND logic assembly of the tetrapeptide.
  • Demonstrated that light, a photobase generator, and an oxidizing agent are sufficient for polymerization.
  • Confirmed reversible aggregation and disaggregation upon redox stimuli.
  • Observed no assembly in a control peptide with a single cysteine residue.

Conclusions:

  • A novel method for light-controlled dynamic covalent assembly of peptides was established.
  • The system exhibits AND logic behavior, requiring multiple stimuli for activation.
  • The dynamic nature of disulfide bonds allows for reversible peptide assembly and disassembly.
  • This approach holds significant potential for programmable molecular assembly in various biological applications.