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Updated: Jun 29, 2025

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
Published on: August 20, 2021
Diagnostic Stewardship for Urine Cultures
K C Coffey1, Kimberley Claeys2, Daniel J Morgan1
1Epidemiology and Public Health, University of Maryland School of Medicine, 10 S. Pine Street, Baltimore, MD 21201, USA.
Most urinary tract infections are diagnosed incorrectly. Diagnostic stewardship can reduce inappropriate antibiotic use for asymptomatic bacteriuria, combating antimicrobial resistance and improving patient safety.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Health Policy
Background:
- Urinary tract infections (UTIs) are common diagnoses in healthcare settings.
- Many UTIs are diagnosed inappropriately in patients lacking infection signs or symptoms.
- Asymptomatic bacteriuria often leads to unnecessary antibiotic prescriptions with adverse consequences.
Purpose of the Study:
- To review diagnostic stewardship methods for combating inappropriate diagnosis and treatment of asymptomatic bacteriuria.
- To highlight the impact of diagnostic stewardship on the diagnostic pathway.
- To provide a practical illustration of diagnostic stewardship principles through a case study.
Main Methods:
- Review of diagnostic stewardship principles and practices.
- Analysis of the impact of stewardship on diagnostic testing and interpretation.
- Presentation of a clinical case study demonstrating stewardship implementation.
Main Results:
- Diagnostic stewardship interventions can decrease the inappropriate detection and treatment of asymptomatic bacteriuria.
- Stewardship strategies aim to optimize the use of diagnostic tests.
- The case study illustrates successful application of stewardship to improve clinical care.
Conclusions:
- Diagnostic stewardship is crucial for appropriate UTI diagnosis and antibiotic use.
- Implementing stewardship reduces the negative downstream effects of overtreatment, such as antimicrobial resistance.
- Optimizing diagnostic pathways through stewardship enhances patient safety and healthcare outcomes.
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