Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

450
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
450

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inter-Observer Variability of Gerd-Related Metrics on High-Resolution Manometry and Calculation of the Milan Score.

Neurogastroenterology and motility·2026
Same author

Neuropsychiatric Outcomes With Tirzepatide, Semaglutide, and Other GLP-1 Receptor Agonists.

Diabetes, obesity & metabolism·2026
Same author

A Rare Adult Ileal Intussusception Caused by Perineurioma.

Diagnostics (Basel, Switzerland)·2026
Same author

Sinus Tachycardia Following Administration of Naloxone in a Dog During Anesthetic Recovery.

Animals : an open access journal from MDPI·2026
Same author

Integrative Transcriptomic and Proteomic Profiling Identifies S100P as a Potential Functional Biomarker for Sessile Serrated Lesions.

Digestive diseases and sciences·2026
Same author

Review Article: Implementation Challenges in Helicobacter pylori Management: Bridging Evidence and Real-World Practice.

Alimentary pharmacology & therapeutics·2026

Related Experiment Video

Updated: Jun 29, 2025

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.3K

Catharanthus roseus intoxication mimicking acute cholangitis.

Yoen Young Chuah1,2, Yeong Yeh Lee3, Chu-Kuang Chou4,5

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ping Tung Christian Hospital, Pingtung, Taiwan.

BMC Complementary Medicine and Therapies
|April 4, 2024
PubMed
Summary

Catharanthus roseus juice can cause toxicity, mimicking acute cholangitis with symptoms like fever and jaundice. Healthcare providers must inquire about herbal supplement use for accurate diagnosis and treatment.

Keywords:
Catharanthus roseus intoxicationCholangitisGastric ulcersJaundiceVinca alkaloids

More Related Videos

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

4.0K
Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
12:36

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

15.9K

Related Experiment Videos

Last Updated: Jun 29, 2025

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.3K
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

4.0K
Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
12:36

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

15.9K

Area of Science:

  • Herbal medicine
  • Toxicology
  • Pharmacology

Background:

  • Catharanthus roseus, a plant native to Madagascar, is recognized for its alkaloid compounds, including those used in chemotherapy.
  • Traditionally, Catharanthus roseus has been used in dried forms (flower and stalks) for medicinal purposes.
  • Despite its therapeutic potential, Catharanthus roseus exhibits toxicity, leading to adverse effects.

Observation:

  • A 65-year-old woman presented with symptoms suggestive of acute cholangitis, including abdominal pain and fever.
  • Imaging studies ruled out common bile duct stones, prompting further investigation into alternative causes.
  • The patient reported ingesting Catharanthus roseus juice for neck pain, revealing a history of herbal supplement use.

Findings:

  • Laboratory results indicated leukocytosis, elevated liver enzymes, and hyperbilirubinemia, consistent with liver injury.
  • The patient developed gastric ulcers, potentially linked to the alkaloid content of Catharanthus roseus.
  • The patient's condition improved significantly after discontinuing the herbal extract, supporting Catharanthus roseus toxicity as the cause.

Implications:

  • Catharanthus roseus toxicity can present with symptoms mimicking acute cholangitis, including fever, hepatotoxicity, cholestatic jaundice, and gastric ulcers.
  • Healthcare providers must obtain comprehensive histories of herbal supplement use to ensure accurate diagnosis and management of potential toxicities.
  • Increased public awareness regarding the risks associated with therapeutic herbs is essential for preventing adverse events and promoting patient safety.