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Related Concept Videos

pre-mRNA Processing02:01

pre-mRNA Processing

52.9K
In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Pre-mRNA Processing: Modification of pre-mRNA Ends01:35

Pre-mRNA Processing: Modification of pre-mRNA Ends

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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps...
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Transcription01:10

Transcription

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Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
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Eukaryotic RNA Polymerases00:58

Eukaryotic RNA Polymerases

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Transfer RNA Synthesis02:35

Transfer RNA Synthesis

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Introduction to 'The Epitranscriptome'.

Ralph E Kleiner1, Claudia Höbartner2, Guifang Jia3

  • 1Department of Chemistry, Princeton University Princeton 08544 NJ USA.

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This summary is machine-generated.

This collection explores the epitranscriptome, focusing on RNA modifications that regulate gene expression. Discover the latest research on these dynamic cellular processes.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • The epitranscriptome, encompassing dynamic RNA modifications, plays a crucial role in post-transcriptional gene regulation.
  • Understanding these modifications is essential for deciphering cellular processes and disease mechanisms.

Discussion:

  • This themed collection highlights recent advancements in epitranscriptome research.
  • It covers novel methodologies and key findings in the study of RNA modifications.

Key Insights:

  • The collection showcases the diverse functions of RNA modifications in various biological contexts.
  • It emphasizes the interplay between epitranscriptomic marks and cellular function.

Outlook:

  • Future research directions in epitranscriptomics are discussed.
  • The potential of targeting the epitranscriptome for therapeutic interventions is explored.