Research progress on oncoprotein hepatitis B X‑interacting protein (Review).

Area of Science:

• Oncology
• Molecular Biology

Background:

• Hepatitis B X-interacting protein (HBXIP), encoded by the Lamtor gene, is a lysosomal membrane protein.
• HBXIP is overexpressed in various cancers, including breast, esophageal, and liver cancers, correlating with specific clinicopathological features.

Approach:

• This review synthesizes current research on HBXIP's multifaceted roles in tumorigenesis.
• It examines HBXIP's normal physiological functions, oncogenic mechanisms, and clinical significance.

Key Points:

• HBXIP enhances tumor cell antioxidant capacity and inhibits ferroptosis.
• It regulates transcriptional, post-transcriptional, and post-translational processes in tumors.
• HBXIP drives metabolic reprogramming and malignant progression in cancer cells.

Conclusions:

• HBXIP is a key driver of tumor progression through diverse molecular mechanisms.
• Further research into HBXIP's carcinogenic pathways is warranted for therapeutic targeting.