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Shared Decision-Making for Partial Oral Antibiotic Treatment of Infective Endocarditis: A Case Series
Sami El-Dalati1, Marice Ruiz Conejo Castillo2, Luke Strnad3
1Division of Infectious Diseases, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky, USA.
Abstract:
Although literature has demonstrated the noninferiority of oral antibiotics in the treatment of infectious endocarditis, widespread adoption of this practice has yet to occur in the United States. We report on 32 patients with infectious endocarditis treated by a multidisciplinary endocarditis team and a standardized approach to partial oral antibiotic therapy with a high rate of clinical success.
Insights
Oral antibiotics are as effective as intravenous options for treating infectious endocarditis. A multidisciplinary team successfully used a standardized partial oral antibiotic approach in 32 patients, achieving high clinical success rates.
Area of Science:
- Infectious Diseases
- Cardiology
- Pharmacology
Background:
- Infectious endocarditis is a serious heart valve infection.
- Oral antibiotics have shown noninferiority to intravenous therapy in clinical studies.
- US adoption of oral antibiotic protocols for endocarditis remains limited.
Purpose of the Study:
- To evaluate the clinical success of a standardized partial oral antibiotic therapy for infectious endocarditis.
- To assess the feasibility of implementing oral antibiotic treatment in a US clinical setting.
Main Methods:
- A retrospective review of 32 patients with infectious endocarditis.
- Treatment guided by a multidisciplinary endocarditis team.
- Standardized partial oral antibiotic regimen administered.
Main Results:
- High rate of clinical success observed in patients treated with the oral antibiotic approach.
- Successful management of infectious endocarditis through a standardized protocol.
Conclusions:
- Partial oral antibiotic therapy is a viable and successful treatment option for infectious endocarditis.
- A multidisciplinary team approach can facilitate the implementation of oral antibiotic protocols.
- Further adoption of oral antibiotics could improve treatment efficiency for infectious endocarditis.
