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Updated: Jun 28, 2025

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

Monochorionic Twinning in Bioengineered Human Embryo Models.

Dorian G Luijkx¹, Asli Ak¹, Ge Guo²

¹MERLN Institute of Technology-Inspired Regenerative Medicine, Department for Instructive Biomaterials Engineering (IBE), Maastricht University, Universiteitssingel 40, Maastricht, 6229ET, The Netherlands.

Advanced Materials (Deerfield Beach, Fla.)

|April 9, 2024

Summary

This summary is machine-generated.

Researchers created human "twin blastoids" from stem cells to study early development. This new model efficiently generates monochorionic twins, offering insights into pregnancy complications and embryonic development.

Keywords:

blastoids implantation‐on‐chip monochorionic twinning stem cell‐based embryo models thermoformed microwell platforms twin embryo models

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Area of Science:

Developmental Biology
Stem Cell Biology
Reproductive Medicine

Background:

Monochorionic twinning in human embryos elevates pregnancy complication risks.
Ethical limitations and rarity hinder in-vivo research on twinning mechanisms.
A significant knowledge gap exists regarding early monochorionic twin development.

Purpose of the Study:

To develop a model system for studying human monochorionic twinning.
To identify conditions that promote efficient monochorionic twin formation in vitro.
To investigate the early developmental characteristics of twin blastoids.

Main Methods:

Utilized a microthermoformed microwell platform for screening.
Generated human stem cell-based blastocyst models (twin blastoids).
Performed morphological, morphokinetic, and implantation assays.

Main Results:

Identified conditions for efficient induction of twin blastoids.
Observed twinning via splitting of the pluripotent core during cavitation.
Twin blastoids exhibited enhanced adhesion capacity in implantation assays.

Conclusions:

Developed a scalable twin blastoid model for studying monochorionic twinning.
The model facilitates systematic exploration of twinning origins and early phenotypes.
This platform offers unprecedented opportunities to understand early embryonic development and implantation potential.