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Cell migration: Collective cell migration is intrinsically stressful.
1MOE Key Laboratory of Model Animals for Disease Study, Jiangsu Key Laboratory of Molecular Medicine, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China.
Current Biology : CB
|April 9, 2024
Summary
Collective cell migration triggers endoplasmic reticulum (ER) stress. An intrinsic cellular mechanism prevents over-reaction to this stress during migration, crucial for development and disease processes.
Area of Science:
- Cell Biology
- Developmental Biology
- Molecular Biology
Background:
- Collective cell migration is fundamental to embryonic development, tissue repair, and cancer metastasis.
- Cellular stress responses, including endoplasmic reticulum (ER) stress, are critical for maintaining cellular homeostasis.
- The interplay between collective cell migration and ER stress has not been fully elucidated.
Purpose of the Study:
- To investigate the induction and role of ER stress during collective cell migration.
- To identify intrinsic mechanisms that regulate cellular responses to ER stress in migrating cell populations.
- To understand how these mechanisms impact cell behavior during collective migration.
Main Methods:
- Utilized live-cell imaging techniques to monitor collective cell migration dynamics.
- Employed biochemical assays to quantify ER stress markers in migrating cells.
- Investigated the function of key regulatory proteins involved in the ER stress response pathway.
Main Results:
- ER stress is significantly induced in cells undergoing collective migration.
- An intrinsic cellular mechanism was identified that attenuates the ER stress response in migratory cells.
- This mechanism ensures that cells maintain migratory capacity without detrimental over-activation of stress pathways.
Conclusions:
- Collective cell migration actively induces ER stress.
- Cells possess a protective intrinsic mechanism to manage ER stress during migration.
- This finding offers new insights into the regulation of cell migration in physiological and pathological contexts.
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