[Changes in lectin-induced agglutination of human tumor cells during the process of their reversion]

The concanavalin A-induced agglutination of cultivated cells of human osteosarcoma Sa-4 was studied in the process of their reversion caused by high polar compounds, dimethylsulphoxide (DMSO) and dimethylformamide (DMFA). Primarily lectin induced an expressed ability to agglutination in Sa-4 cells. In the process of tumour cell reversion under the effect of chemical inducers their agglutination decreases. After the DMSO and DMFA removal the osteosarcoma cells return to their initial state showing a high agglutination. Other high-polar compounds (N-methylformamide and dimethylacetamide) induced no reversion of Sa-4 cells and no agglutination of them as well.