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Recurrent Adamantinoma With Fibrous Dysplasia-like Feature
Anja Petaros1, Veljko Šantić2, Anita Savić Vuković3
1Department of Forensic Medicine and Criminalistics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Clinical Pathology (Thousand Oaks, Ventura County, Calif.)
|April 10, 2024
Summary
Adamantinoma, a rare bone tumor, can mimic fibrous dysplasia, complicating diagnosis. Immunohistochemistry is crucial for accurate identification, especially in recurrent or morphologically varied lesions.
Area of Science:
- Oncology
- Pathology
- Orthopedics
Background:
- Adamantinoma (AD) is a rare, biphasic primary bone tumor.
- AD is often associated with osteofibrous dysplasia (OFD) but rarely with fibrous dysplasia (FD).
Observation:
- A case of AD presented with classical AD and osteofibrous-like patterns in initial biopsies.
- Recurrent lesions showed exclusively spindle cell morphology, mimicking FD.
- Immunohistochemical analysis revealed characteristic AD markers (pancytokeratin, vimentin, p63, podoplanin) across all lesions.
Findings:
- The study highlights diagnostic challenges of AD due to variable morphology and potential misdiagnosis as FD.
- Immunohistochemistry, particularly for keratin and podoplanin, is vital for differentiating AD from FD-like lesions.
Implications:
- Accurate diagnosis of adamantinoma requires considering immunohistochemical markers alongside histopathology.
- This case underscores the importance of comprehensive evaluation for bone tumors with diverse presentations.
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