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Updated: Jun 28, 2025
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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
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Lymphovascular Invasion in Cutaneous Squamous Cell Carcinoma
Michael P Ryan1, Frank T Winsett2, Andrew M Armenta2
1Department of Dermatology, University of Texas Health Science Center at Houston, Houston, Texas.
Summary
Lymphovascular invasion (LVI) is a significant risk factor for poor outcomes in cutaneous squamous cell carcinoma (cSCC). Management of cSCC with LVI should align with high-risk tumors, similar to those with perineural invasion (PNI).
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Limited research exists on lymphovascular invasion (LVI) in cutaneous squamous cell carcinoma (cSCC).
- Established literature on perineural invasion (PNI) in cSCC contrasts with the scarcity of data on LVI.
- Lack of clear clinical management guidelines for cSCC with LVI.
Purpose of the Study:
- To review existing literature on lymphovascular invasion (LVI) in cutaneous squamous cell carcinoma (cSCC).
- To develop evidence-based recommendations for managing cSCC patients with LVI.
Main Methods:
- A comprehensive literature review was performed.
- PubMed database was utilized to identify relevant studies.
- Focus on outcomes and management of primary cSCC with LVI.
Main Results:
- Lymphovascular invasion (LVI) is identified as a major risk factor.
- LVI is associated with poorer patient outcomes.
- Increased morbidity and mortality linked to LVI in cSCC.
Conclusions:
- Lymphovascular invasion (LVI) represents a high-risk feature in cSCC.
- cSCC tumors with LVI should be classified in the highest-risk category.
- Management strategies for LVI in cSCC should mirror those for PNI.
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