Recent Advances in π-Stacking Interaction-Controlled Asymmetric Synthesis.

Area of Science:

• Organic Chemistry
• Supramolecular Chemistry
• Asymmetric Synthesis

Background:

• Pi-stacking interactions are fundamental noncovalent forces in organic chemistry.
• These interactions stabilize structures and transition states, influencing reaction selectivity (chemo-, regio-, stereoselectivities).

Purpose of the Study:

• To review recent advancements in asymmetric synthesis controlled by pi-stacking interactions.
• To showcase diverse applications of pi-stacking in creating complex chiral molecules.

Main Methods:

• Literature review of recent studies on pi-stacking controlled reactions.
• Focus on examples including auxiliary-induced synthesis, kinetic resolution, and synthesis of complex chiral architectures.

Main Results:

• Demonstrated the pivotal role of pi-stacking in achieving high selectivity in various asymmetric transformations.
• Highlighted successful applications in synthesizing challenging chiral molecules like helicenes and 3D chiral systems.

Conclusions:

• Pi-stacking interactions offer powerful control in asymmetric synthesis.
• Recent examples showcase the expanding utility of pi-stacking for constructing intricate chiral molecules and materials.