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Published on: September 8, 2023
Influence of Various Strontium Formulations (Ranelate, Citrate, and Chloride) on Bone Mineral Density, Morphology,
Agnieszka Tomczyk-Warunek1, Karolina Turżańska2, Agnieszka Posturzyńska2
1Laboratory of Locomotor Systems Research, Department of Rehabilitation and Physiotherapy, Medical University of Lublin, 20-954 Lublin, Poland.
Abstract:
Osteoporosis stands out as a prevalent skeletal ailment, prompting exploration into potential treatments, including dietary strontium ion supplements. This study assessed the efficacy of supplementation of three strontium forms-strontium citrate (SrC), strontium ranelate (SrR), and strontium chloride (SrCl)-for enhancing bone structure in 50 female SWISS mice, aged seven weeks. In total, 40 mice underwent ovariectomy, while 10 underwent sham ovariectomy. Ovariectomized (OVX) mice were randomly assigned to the following groups: OVX (no supplementation), OVX + SrR, OVX + SrC, and OVX + SrCl, at concentrations equivalent to the molar amount of strontium. After 16 weeks, micro-CT examined trabeculae and cortical bones, and whole-bone strontium content was determined. Results confirm strontium administration increased bone tissue mineral density (TMD) and Sr content, with SrC exhibiting the weakest effect. Femur morphometry showed limited Sr impact, especially in the OVX + SrC group. This research highlights strontium's potential in bone health, emphasizing variations in efficacy among its forms.
Insights
Dietary strontium supplements show potential for improving bone health in osteoporosis models. Strontium ranelate and strontium chloride were more effective than strontium citrate in enhancing bone density and strontium content.
Area of Science:
- Biomineralization
- Skeletal Biology
- Pharmacology
Background:
- Osteoporosis is a common skeletal disease affecting bone structure.
- Dietary strontium ion supplements are being investigated as a potential treatment.
- Understanding the efficacy of different strontium forms is crucial for therapeutic development.
Purpose of the Study:
- To evaluate the efficacy of three strontium forms (strontium citrate, strontium ranelate, strontium chloride) in enhancing bone structure.
- To compare the effects of different strontium supplements on bone mineral density and strontium content in an osteoporosis model.
Main Methods:
- Fifty female SWISS mice (7 weeks old) were used, with 40 undergoing ovariectomy (OVX) and 10 a sham procedure.
- OVX mice were divided into four groups: OVX control, OVX + strontium ranelate, OVX + strontium citrate, and OVX + strontium chloride.
- Bone microarchitecture was analyzed using micro-CT, and whole-bone strontium content was measured after 16 weeks of supplementation.
Main Results:
- Strontium administration significantly increased bone tissue mineral density (TMD) and bone strontium content across groups.
- Strontium citrate (SrC) demonstrated the weakest positive effect on bone parameters compared to other forms.
- Femur morphometry indicated limited impact of strontium, particularly in the OVX + SrC group.
Conclusions:
- Strontium supplementation holds promise for improving bone health in osteoporosis.
- The efficacy of strontium in enhancing bone structure varies significantly among different chemical forms.
- Strontium ranelate and strontium chloride appear more beneficial than strontium citrate for bone health in this OVX mouse model.
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