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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

622
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
622
Allergic Reactions02:06

Allergic Reactions

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Overview
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
839

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Updated: Jun 28, 2025

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Patch Testing in Allergic Contact Dermatitis.

Rashmi Sharma1, Dwarika Prasad Shrestha2

  • 1National Academy of Medical Sciences, Bir Hospital, Kathmandu.

Journal of Nepal Health Research Council
|April 14, 2024
PubMed
Summary
This summary is machine-generated.

Nickel sulfate is the most common allergen causing allergic contact dermatitis in Nepal, identified through patch testing. This study highlights the importance of allergen identification for effective patient management and prevention strategies.

Keywords:
Allergens; allergic contact dermatitis; nickel; patch test.

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Area of Science:

  • Dermatology
  • Allergology
  • Epidemiology

Background:

  • Allergic contact dermatitis (ACD) is a prevalent skin condition necessitating medical attention.
  • Accurate allergen identification via patch testing is crucial for managing ACD.
  • Understanding regional allergen prevalence is vital for public health initiatives.

Purpose of the Study:

  • To identify the types and frequency of allergens causing ACD in a Nepalese tertiary hospital.
  • To establish a baseline for allergen sensitivity in the Nepalese population.

Main Methods:

  • A study involving 120 patients diagnosed with ACD.
  • Patch testing using the Indian Standard Series of allergens.
  • Results were evaluated at 48 and 96 hours, with reactions graded using International Contact Dermatitis Research Group criteria.

Main Results:

  • 53% of patients tested positive for at least one allergen.
  • Nickel sulfate was the most frequent sensitizer (18%), followed by Fragrance mix (9%) and Paraphenylenediamine (6%).
  • Most positive reactions were mild (Grade 1: 51%) or moderate (Grade 2: 47%).

Conclusions:

  • Patch testing is effective for ACD diagnosis, treatment, and patient counseling.
  • Further large-scale studies are needed to determine allergen sensitivity in the broader Nepalese population.