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Drugs for Treatment of Constipation-Predominant IBS01:21

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
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Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

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Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
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Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
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Constipation anti-aging effects by dairy-based lactic acid bacteria.

Mohamad Hafis Jaafar1, Pei Xu1,2, Uma-Mageswary Mageswaran1

  • 1Bioprocess Technology, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia.

Journal of Animal Science and Technology
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Dairy-isolated lactic acid bacteria (LAB) strains improved constipation in aging rats. These probiotics softened stools and increased moisture, offering a potential dietary intervention for age-related digestive issues.

Keywords:
AgingConstipationDairy foodsDairy-based lactic acid bacteria (LAB)Probiotics

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Gerontology

Background:

  • Constipation is a common health issue in aging animals and livestock.
  • Aging can exacerbate defecation difficulties and infrequent bowel movements.
  • Current treatments may have limitations, necessitating alternative interventions.

Purpose of the Study:

  • To evaluate the efficacy of dairy-isolated lactic acid bacteria (LAB) strains in alleviating constipation in an aging rat model.
  • To explore LAB as a potential therapeutic intervention for age-related constipation.
  • To investigate the impact of specific LAB strains on physiological and metabolic markers of constipation.

Main Methods:

  • Rats were subjected to aging using D-galactose and constipation was induced with loperamide hydrochloride.
  • Administration of *Lactobacillus fermentum* USM 4189 or *Lactobacillus plantarum* USM 4187 via oral gavage.
  • Assessment of fecal characteristics (Bristol Stool Chart, moisture content), fecal metabolite profiles, and colonic histopathology.

Main Results:

  • LAB administration resulted in softer stools and increased fecal moisture content compared to the control group.
  • Fecal analysis revealed a reduced concentration of threonine in rats treated with LAB.
  • Histopathological examination showed a higher colonic goblet cell count in the LAB-treated groups.

Conclusions:

  • Dairy-sourced LAB strains demonstrate potential as probiotics to ameliorate constipation associated with aging.
  • These LAB strains may serve as a viable dietary intervention strategy, particularly in dairy products like yogurt and cheese.
  • Further research into LAB for managing age-related constipation is warranted.