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Nitric oxide and viral infection: Recent developments in antiviral therapies and platforms

Mark R Garren1, Morgan Ashcraft1,2, Yun Qian1

  • 1School of Chemical, Materials, and Biochemical Engineering, College of Engineering, University of Georgia, Athens, GA, USA.

Applied Materials Today
|April 15, 2024
PubMed

Keywords:
ACE, angiotensin converting enzymeAP1, activator protein 1COVID-19COVID-19, coronavirus disease 2019ECMO, extracorporeal membrane oxygenation, FDA, United States Food and Drug AdministrationGNSO, S-nitrosoglutathioneH1N1, influenza A virus subtype H1N1HI, Host ImmunologyHIV, human immunodeficiency virusHPV, human papillomavirusHSV, herpes simplex virusI/R, pulmonary ischemia-reperfusionIC50, inhibitory concentration 50IFN, interferonIFNγ, interferon gammaIKK, inhibitor of nuclear factor kappa B kinaseIRF-1, interferon regulatory factor 1Inhalation therapyMedical Terminology: ARDS, acute respiratory distress syndromeNF-κB, nuclear factor kappa-light-chain enhancer of activated B cellsNO, nitric oxideNOS, nitric oxide synthaseNitric Oxide and Related Compounds: eNOS/NOS 3, endothelial nitric oxide synthaseNitric oxideOther: DNA, deoxyribonucleic acidP38-MAPK, P38 mitogen-activated protein kinasesPAMP, pathogen-associated molecular patternPCV2, porcine circovirus type 2PHT, pulmonary hypertensionPKR, protein kinase RRNA, ribonucleic acidRNI, reactive nitrogen intermediateRSNO, S-nitrosothiolSARS, severe acute respiratory syndromeSARS-CoV-2, severe acute respiratory syndrome coronavirus 2SNAP, S-nitroso-N-acetyl-penicillamineSTAT-1, signal transducer and activator of transcription 1Severe acute respiratory distressTAK1, transforming growth factor β-activated kinases-1TLR, toll-like receptorVAP, ventilator associated pneumoniaViral infectionViruses: CVB3, coxsackievirusdsRNA, double stranded (viral) ribonucleic acidgNO, gaseous nitric oxideiNOS/NOS 2, inducible nitric oxide synthasemtALDH, mitochondrial aldehyde dehydrogenasenNOS/NOS 1, neuronal nitric oxide synthase

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