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A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
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Virus-like particles derived from bacteriophage MS2 as antigen scaffolds and RNA protective shells
Antonina Naskalska1, Jonathan Gardiner Heddle1,2
1Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, 30-392, Poland.
Nanomedicine (London, England)
|April 17, 2024
Summary
Bacteriophage MS2 virus-like particles (VLPs) show great potential in biotechnology. This review highlights their use as vaccine scaffolds and RNA delivery systems.
Area of Science:
- Biotechnology
- Virology
- Materials Science
Background:
- Bacteriophage MS2-derived virus-like particles (VLPs) have been researched for 30 years.
- MS2 VLPs are produced in high yield and are easily engineered.
- VLPs offer potential as protective capsules and delivery platforms.
Purpose of the Study:
- To review the progress of MS2 VLPs in two key areas.
- Focus on vaccine development and nucleic acid delivery.
Main Methods:
- Engineering MS2 VLPs as scaffolds for displaying epitopes.
- Utilizing MS2 VLPs as capsids for encapsulating foreign RNA.
Main Results:
- MS2 VLPs serve as effective scaffolds for vaccine development.
- MS2 VLPs demonstrate utility in delivering foreign RNA.
Conclusions:
- MS2 VLPs are versatile tools in medical biotechnology.
- Continued development holds promise for novel therapeutic and diagnostic applications.
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