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Related Concept Videos

Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

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Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
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Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
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Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

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Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Related Experiment Video

Updated: May 6, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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Tubulointerstitial Nephritis and Uveitis: A Case Report.

Michael Mira1, Yuriy Khanin2, Miroslav Sekulic3

  • 1Internal Medicine, Overlook Medical Center, Summit, USA.

Cureus
|April 18, 2024
PubMed
Summary
This summary is machine-generated.

Tubulointerstitial nephritis and uveitis (TINU) is a rare condition. This case highlights severe TINU symptoms requiring prompt corticosteroid treatment to preserve kidney function, with potential for recurrence.

Keywords:
acute kidney diseaseacute kidney injurytinutubulointerstitial nephritis and uveitis syndrometubulointerstitial nephritis with uveitis

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Area of Science:

  • Nephrology
  • Ophthalmology
  • Rheumatology

Background:

  • Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare autoimmune disease.
  • Its pathogenesis remains largely unknown, typically presenting with mild, self-limiting uveitis and nephritis.

Observation:

  • A 29-year-old female with a history of cytomegalovirus (CMV) presented with severe bilateral uveitis and acute renal insufficiency.
  • Laboratory results showed hematuria and proteinuria, and kidney biopsy confirmed tubulointerstitial nephritis.

Findings:

  • The patient received corticosteroids for TINU, achieving baseline renal function after three months.
  • However, uveitis recurred during steroid taper, necessitating steroid-sparing therapies.

Implications:

  • TINU syndrome should be considered in patients with concurrent uveitis and renal dysfunction.
  • Early corticosteroid intervention is crucial for preserving renal function.
  • The variable prognosis and frequent relapses underscore the need for further research into optimal treatment strategies.