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Mannose Binding Lectin and C3 Serum Levels in Coronary Artery Disease: A Cross-Sectional Study
Juliana Meneghetti da Rosa1, Kárita Cláudia Freitas Lidani1, Fabiana Antunes Andrade1,2
1Laboratory of Molecular Immunopathology, Clinical Hospital, Federal University of Paraná (HC-UFPR), Curitiba, Brazil.
Insights
Mannose-binding lectin (MBL) serum levels are higher in patients with coronary artery disease (CAD). C3 levels correlate with cardiovascular risk factors like BMI and triglycerides, not CAD itself.
Area of Science:
- Immunology
- Cardiology
- Biochemistry
Background:
- Coronary artery disease (CAD) involves tissue injury linked to complement system activation.
- Mannose-binding lectin (MBL) and C3 are complement proteins found in atherosclerotic lesions.
Purpose of the Study:
- To measure serum levels of MBL and C3 in CAD patients and healthy controls.
- To investigate the association between MBL and C3 levels and cardiometabolic parameters in CAD.
Main Methods:
- Serum MBL and C3 concentrations were quantified using ELISA and immunoturbidimetry.
- The study included 119 CAD patients (48 with acute myocardial infarction) and 93 healthy controls.
Main Results:
- CAD patients exhibited significantly higher MBL serum concentrations compared to controls (p=.002).
- Elevated MBL levels (>2000 ng/mL) were more prevalent in CAD patients (OR=2.6).
- C3 levels showed no significant difference between groups but correlated positively with BMI and triglycerides.
Conclusions:
- Elevated MBL concentrations are associated with the presence of CAD.
- C3 levels are linked to cardiovascular risk factors rather than CAD directly.
Background:
The process of tissue injury in coronary artery disease (CAD) has been associated with activation of the complement system, partly due to the action of mannose-binding lectin (MBL) and C3, which are expressed in atherosclerotic lesions.
Objective:
The aim of this study was to evaluate the serum levels of MBL and C3 in patients with CAD and to compare them with healthy controls. Additionally, we aim to assess the correlation between MBL and C3 levels and cardiometabolic parameters.
Methods:
MBL and C3 serum concentration were determined by ELISA and immunoturbidimetry, respectively, in up to 119 patients undergoing coronary angiography for CAD evaluation, comprising 48 individuals diagnosed with acute myocardial infarction (MI) and 71 without MI. A total of 93 paired healthy controls were included in the study.
Results:
Individuals with CAD had MBL serum concentration higher than controls (p = .002), regardless of the presence of MI (p = .006). In addition, high concentration of MBL (>2000 ng/mL) was more frequent in patients with CAD (p = .007; OR = 2.6; 95% CI = 1.3-5.1). C3 levels were not significantly associated with any of the patient groups but were positively correlated with cardiometabolic parameters such as body mass index (BMI) and triglycerides levels.
Conclusions:
Higher concentrations of MBL were found to be associated with CAD, whereas C3 levels were found to be associated with cardiovascular risk factors.
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