Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Therapies02:49

Cancer Therapies

7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Tumor Immunotherapy01:27

Tumor Immunotherapy

522
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
522
Cancer Vaccines01:30

Cancer Vaccines

360
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
360

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cancer Neuroscience: Innovative Conception and Emerging Strategy of Therapy.

MedComm·2026
Same author

Astrocytes in neuroinflammation and brain cancer.

Molecular biomedicine·2026
Same author

Reprogramming neural-tumor crosstalk: emerging therapeutic dimensions and targeting strategies.

Military Medical Research·2025
Same author

TRAILblazing Astrocytes: Glioblastoma's Covert Immunosuppressive Agents.

Neuroscience bulletin·2025
Same author

Liver cirrhosis: molecular mechanisms and therapeutic interventions.

MedComm·2024
Same author

Diapause-like Drug-Tolerant Persister State: The Key to Nirvana Rebirth.

Medicina (Kaunas, Lithuania)·2024

Related Experiment Video

Updated: Jun 28, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K

Drug repurposing for cancer therapy.

Ying Xia1,2,3,4, Ming Sun1,3, Hai Huang5,6

  • 1Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, PR China.

Signal Transduction and Targeted Therapy
|April 18, 2024
PubMed
Summary

Drug repurposing offers a cost-effective and safe strategy to develop novel cancer therapeutics. This review explores methods, antitumor properties, and the integration of repurposed drugs with nanotechnology and combination therapy for improved cancer treatment.

More Related Videos

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.2K
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
09:56

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

504

Related Experiment Videos

Last Updated: Jun 28, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K
Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.2K
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
09:56

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

504

Area of Science:

  • Oncology
  • Pharmacology
  • Drug Discovery

Background:

  • Cancer remains a major global health challenge, with drug therapy efficacy limited by resistance and toxicity.
  • Novel cancer therapeutics are critically needed to overcome these limitations.
  • Drug repurposing, identifying new uses for existing drugs, is a promising strategy.

Purpose of the Study:

  • To provide a comprehensive overview of drug repurposing methods for cancer treatment.
  • To describe the antitumor properties of candidate repurposed drugs.
  • To examine the integration of drug repurposing with nanotechnology and combination therapy.

Main Methods:

  • Review of existing literature on drug repurposing in oncology.
  • Analysis of antitumor mechanisms targeting cancer hallmarks and the tumor microenvironment.
  • Exploration of nanotechnology and combination therapy approaches.

Main Results:

  • Repurposed drugs are cost-effective, safe, and accelerate development.
  • Candidate drugs target cancer hallmarks and the tumor microenvironment.
  • Integration with nanotechnology and combination therapy enhances efficacy.

Conclusions:

  • Drug repurposing presents significant advantages for cancer treatment development.
  • Challenges in clinical translation exist, but future prospects are promising.
  • Repurposed drugs hold potential for improved patient outcomes in oncology.