Flexible multifunctional titania nanotube array platform for biological interfacing

Area of Science:

• Biomaterials Engineering
• Nanotechnology
• Tissue Engineering

Background:

• Titania nanotube arrays (TNAs) are biocompatible nanomaterials with drug-eluting capabilities.
• Current applications of TNAs are primarily for rigid tissue integration (e.g., dental, orthopedic).
• There is a need for flexible nanomaterials for soft tissue interfaces and implantable devices.

Purpose of the Study:

• To develop a flexible, multifunctional platform using TNAs for biological interface applications.
• To evaluate the biocompatibility of TNAs with neural cells.
• To assess the drug release kinetics of dexamethasone from TNA-polymer substrates under mechanical stress.

Main Methods:

• Cultured microglia cells on TNA surfaces for *in vitro* biocompatibility testing.
• Fabricated flexible TNAs-on-polyimide substrates.
• Evaluated dexamethasone release profiles under various bending conditions.
• Developed microfabrication techniques for TNA patterning and transfer.

Main Results:

• TNAs demonstrated *in vitro* biocompatibility with microglia cells.
• Flexible TNA-polyimide substrates sustained linear release of dexamethasone for up to 11 days.
• Developed microfabrication methods enable TNA integration onto diverse polymer substrates.

Conclusions:

• Flexible TNAs offer a promising platform for soft-tissue interfaces and drug delivery.
• The developed fabrication techniques facilitate the integration of TNAs onto various flexible substrates.
• This technology holds potential for creating advanced, compliant implantable devices.