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Cutaneous T-cell Lymphomas: A Single-center Retrospective Analysis
Till Kaemmerer1, Anne Guertler, Benjamin M Clanner-Engelshofen
1Till Kämmerer, MD, Department of Dermatology and Allergy University Hospital, LMU Munich, Frauenlobstr. 9-11, till.kaemmerer@med.uni-muenchen.de.
Acta Dermatovenerologica Croatica : ADC
|April 23, 2024
Summary
This study evaluated 102 patients with cutaneous T-cell lymphomas (CTCLs), primarily mycosis fungoides (MF) and Sézary syndrome (SS). Early-stage CTCLs were treated with skin-directed therapy, while advanced stages required systemic or combined approaches.
Area of Science:
- Dermatology
- Oncology
- Hematology
Background:
- Cutaneous T-cell lymphomas (CTCLs) are rare skin cancers involving malignant T-cells.
- This study focuses on the epidemiology and treatment of CTCLs, particularly mycosis fungoides (MF) and Sézary syndrome (SS).
Purpose of the Study:
- To evaluate the prevalence, epidemiology, and therapeutic approaches for CTCLs.
- To analyze treatment strategies for MF and SS in a German university outpatient clinic.
Main Methods:
- Retrospective analysis of medical data from 102 CTCL patients diagnosed between January 2015 and December 2019.
- Patients were classified by subtype (MF or SS) and disease stage (ISCL/EORTC criteria).
Main Results:
- The majority of patients (90%) had MF, with most diagnosed at early stages (IA and IB).
- Skin-directed therapy (SDT) was used initially for 44.1% of patients, with 19.6% progressing to systemic therapy (ST).
- Combined ST and SDT was initiated upfront for 36.3%, with diverse therapeutic approaches used for non-responders or progressive disease.
Conclusions:
- CTCL management prioritizes quality of life and symptom control due to the typically incurable nature of the disease.
- The study supports a treatment paradigm favoring topical therapies for early-stage CTCLs and more invasive options for advanced stages.
- Findings provide a valid evaluation of CTCL frequency and therapy in a German academic setting.
