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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Related Experiment Video

Updated: Jun 28, 2025

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
06:15

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

864

Acute rejection post lung transplant.

Justin Hanks1, Christine Girard, Sameep Sehgal

  • 1Department of Pulmonary Medicine, Integrated Hospital Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Current Opinion in Pulmonary Medicine
|April 24, 2024
PubMed
Summary
This summary is machine-generated.

Acute rejection (AR) in lung transplantation impacts graft function and chronic rejection risk. While histopathology is key, new molecular methods show promise for earlier AR detection and diagnosis.

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Area of Science:

  • Immunology
  • Transplantation Medicine
  • Pulmonology

Background:

  • Acute rejection (AR) is a primary cause of early lung graft dysfunction.
  • AR escalates the risk of developing chronic lung allograft dysfunction.
  • AR presents as acute cellular rejection (ACR) or antibody-mediated rejection (AMR), or both.

Purpose of the Study:

  • To review current knowledge on lung transplant acute rejection (AR).
  • To cover AR pathogenesis, diagnosis, treatment, and prevention.
  • To highlight emerging diagnostic tools for AR.

Main Methods:

  • Review of current literature on lung transplantation and AR.
  • Analysis of diagnostic criteria for ACR and AMR.
  • Examination of treatment strategies for ACR and AMR.

Main Results:

  • Histopathology remains the gold standard for AR diagnosis.
  • Epigenomic and transcriptomic methods are emerging for early AR detection.
  • ACR diagnosis relies on transbronchial biopsy; AMR requires donor-specific antibody (DSA) measurement.
  • ACR treatment involves enhanced immunosuppression; AMR treatment focuses on DSA removal.

Conclusions:

  • Early detection and accurate diagnosis of AR are crucial for lung transplant outcomes.
  • Noninvasive molecular diagnostics are under investigation to complement histopathology.
  • Tailored treatment strategies for ACR and AMR are essential for managing lung allograft rejection.