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A Single-Component Janus Zwitterionic Hydrogel Patch with a Bionic Microstructure for Postoperative Adhesion

Rui Liu1, Zhongming Zhao1, Qi Yang1

  • 1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China.

ACS Applied Materials & Interfaces
|April 26, 2024
PubMed
Summary

This study introduces a novel Janus zwitterionic hydrogel patch with a bionic microstructure to prevent postoperative adhesions. Its unique design ensures tissue retention and antifouling properties, outperforming commercial controls in vivo.

Keywords:
Janusadhesion preventionantifoulingbionic microstructureretention in situwet adhesionzwitterionic hydrogel

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Postoperative adhesions remain a significant clinical challenge, impacting patient recovery and requiring revision surgeries.
  • Existing anti-adhesion strategies often struggle to balance effective tissue retention with robust antifouling capabilities.

Purpose of the Study:

  • To develop and evaluate a novel single-component Janus zwitterionic hydrogel patch with a bionic microstructure for preventing postoperative adhesions.
  • To assess the hydrogel's dual functionality: in situ tissue retention and antifouling properties.

Main Methods:

  • Janus hydrogel patches were synthesized using free radical polymerization of sulfobetaine methacrylate.
  • A bionic microstructure with hexagonal facets and grooves was engineered onto one surface for tissue retention.
  • The opposing surface utilized zwitterionic polymers for antifouling properties.
  • In vivo studies on abdominal wall cecum injuries were conducted to evaluate anti-adhesion efficacy.

Main Results:

  • The bionic microstructure facilitated rapid drainage and enhanced adhesion strength to traumatized tissues.
  • The zwitterionic surface demonstrated excellent resistance to protein and cell adhesion.
  • In vivo experiments showed superior anti-adhesion performance compared to commercial controls.
  • The Janus hydrogel patches exhibited a mutually embedded structure with tissue, minimizing slippage.

Conclusions:

  • The Janus zwitterionic hydrogel patch effectively prevents postoperative adhesions through its dual-function design.
  • The bionic microstructure is crucial for durable in situ retention and enhanced adhesion.
  • This hydrogel presents significant potential for clinical applications in averting postoperative adhesions.