Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Introduction to the Human Microbiota

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...

Microbiota of the Urogenital Tract

Microbiota of the Urogenital Tract

The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

<i>Ex vivo</i> feasibility study of vasovasostomy utilizing a novel microsurgery platform versus manual microsurgery.

Translational andrology and urology·2026

Same author

Povidone-iodine for transrectal prostate biopsy.

The Cochrane database of systematic reviews·2025

Same author

The Influence of the Germline <i>HSD3B1</i> Adrenal-Permissive Allele (c.1100 C) on the Somatic Alteration Landscape, the Transcriptome, and Immune Cell Infiltration in Prostate Cancer.

Cancers·2025

Same author

Transurethral Water Vapor Ablation: Potential for a Novel Prostate Cancer Management Strategy.

Research and reports in urology·2025

Same author

Current uses and resistance mechanisms of enzalutamide in prostate cancer treatment.

Expert review of anticancer therapy·2024

Same author

Pan-Cancer Interrogation of B7-H3 (CD276) as an Actionable Therapeutic Target Across Human Malignancies.

Cancer research communications·2024

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Prostate Tissue Microbiome in Patients with Prostate Cancer: A Systematic Review.

Daniela F Ward Grados¹, Onuralp Ergun¹, Carly D Miller¹

¹Department of Urology, University of Minnesota, Minneapolis, MN 55455, USA.

|April 27, 2024

Summary

This summary is machine-generated.

The prostatic microbiome may link to prostate cancer (PCa), with potential associations found for specific bacteria and viruses. However, current data is limited, requiring further research for definitive conclusions on PCa pathogenesis.

Keywords:

Cutibacterium microbiota prostate cancer prostate microbiome

More Related Videos

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Published on: October 10, 2019

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

Related Experiment Videos

Last Updated: Jun 17, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Published on: October 10, 2019

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

Area of Science:

Microbiology
Oncology
Urology

Background:

The role of the prostatic microbiome in prostate cancer (PCa) development is under investigation.
Existing research lacks consensus on specific microbial associations in PCa versus healthy prostate tissue.

Purpose of the Study:

To systematically review and compare the prostatic tissue microbiome in PCa patients and healthy controls.
To identify potential microbial associations with PCa pathogenesis.

Main Methods:

Systematic literature search of MEDLINE, Embase, and Scopus databases.
Screening of articles by two independent, blinded reviewers.
Inclusion of studies comparing prostatic tissue microbiome in PCa patients and benign controls.

Main Results:

Potential associations between PCa and increased *Propionibacterium acnes*, *Mycoplasma genitalium*, and the viral families *Herpesviridae* and *Papillomaviridae* were noted.
Significant challenges in data interpretation due to difficulties in obtaining uncontaminated samples, lack of healthy controls, varied methodologies, and inconsistent organism selection.

Conclusions:

Current evidence suggests a possible link between the prostatic microbiome and PCa, but definitive conclusions cannot be drawn.
Further research with standardized methods and adequate controls is necessary to elucidate the role of the prostatic microbiome in PCa pathogenesis.