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Navigating biologic therapies in elderly asthma
HyeIn Ji1, Laren D Tan2, George W Hafzalla1
1Department of Medicine, Loma Linda University Health, Loma Linda, CA, USA.
Respiratory Medicine
|April 28, 2024
Summary
Biologic therapies show promise for severe asthma in older adults, but research is lacking. Future studies must include elderly patients to improve treatment and outcomes for this growing population.
Area of Science:
- Gerontology
- Pulmonology
- Pharmacology
Background:
- Asthma prevalence is increasing in the elderly, posing diagnostic and management challenges.
- Biologic therapies target severe asthma pathways effectively in elderly individuals.
- A significant research gap exists regarding biologic therapy application in elderly asthma patients.
Purpose of the Study:
- To review the current landscape of biologic therapies for elderly asthma patients.
- To highlight the need for dedicated clinical trials and research including elderly participants.
- To discuss challenges and considerations for using biologic therapies in this demographic.
Main Methods:
- Review of existing literature on biologic therapies for asthma in the elderly.
- Analysis of clinical trial designs and exclusion criteria impacting elderly inclusion.
- Examination of observational studies on biologic therapy efficacy and safety in older adults.
Main Results:
- No randomized controlled trials (RCTs) are specifically designed for the elderly across all asthma biologics.
- Most RCTs exclude elderly individuals or those with common comorbidities.
- Observational studies suggest comparable benefits of biologics in elderly versus non-elderly adults.
Conclusions:
- Elderly asthma patients are underrepresented in research, hindering evidence-based treatment.
- There is a critical need for intentional inclusion of elderly participants in future clinical trials.
- Tailored, evidence-based approaches are essential to optimize biologic therapy for elderly asthma patients.
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