Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.4K
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

574
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
574
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

422
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
422
Human Genetics01:28

Human Genetics

564
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
564

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety of Biologic Therapy in Psoriasis Patients With Malignancy.

Journal of the American Academy of Dermatology·2026
Same author

Clinical Potential of Antimicrobial Photodynamic Therapy.

Journal of the American Academy of Dermatology·2026
Same author

Platelet-neutrophil cooperation in cancer: mechanisms of metastatic niche formation and implications for prognostic stratification and therapy.

Cellular oncology (Dordrecht, Netherlands)·2026
Same author

Association of Intratumoral Microbiota with Prognosis in Head and Neck Squamous Cell Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC.

The New England journal of medicine·2026
Same author

TYK2 and IL-23 Pathway Therapies in Psoriasis: Associations With IL-6, Tryptophan Metabolism, and Depressive Symptoms.

International journal of dermatology·2026

Related Experiment Video

Updated: Jun 27, 2025

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
05:08

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

Published on: October 3, 2019

11.1K

The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study.

Jun Liu1,2, Gujie Wu3, Shuqi Li2

  • 1Department of Health Management, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.

Frontiers in Endocrinology
|April 29, 2024
PubMed
Summary

This study establishes a genetic causal link between hyperthyroidism and an increased risk of heart failure. These findings suggest thyroid dysfunction may directly contribute to heart failure development.

Keywords:
SNPsall-cause heart failureheart failurehyperthyroidismthyroid diseasetwo-sample Mendelian randomization (MR)

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.1K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.6K

Related Experiment Videos

Last Updated: Jun 27, 2025

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
05:08

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

Published on: October 3, 2019

11.1K
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.1K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.6K

Area of Science:

  • Endocrinology
  • Cardiology
  • Genetics

Background:

  • Hyperthyroidism is an endocrine disorder with diverse causes and symptoms.
  • Heart failure (HF) is a significant clinical condition with high morbidity and mortality.
  • While thyroid dysfunction is linked to heart disease, a causal relationship with HF remains unproven.

Purpose of the Study:

  • To investigate the potential causal relationship between hyperthyroidism and heart failure.
  • To explore the genetic basis of the association between hyperthyroidism and HF.

Main Methods:

  • Utilized two-sample Mendelian randomization (MR) analysis.
  • Employed summary data from a large genetic association study on hyperthyroidism.
  • Analyzed genetically determined all-cause heart failure data from the FinnGen Consortium (218,208 individuals).
  • Applied various statistical methods including inverse variance-weighted, weighted median, and MR-Egger.

Main Results:

  • Inverse variance-weighted analysis revealed a significant causal association between hyperthyroidism and increased risk of all-cause heart failure (OR=1.049, P=0.007).
  • Weighted median analysis corroborated this finding, showing a positive correlation (OR=1.049, P=0.044).
  • No significant horizontal pleiotropy or heterogeneity was detected, and leave-one-out analysis confirmed robustness.

Conclusions:

  • This study provides evidence for a causal relationship between hyperthyroidism and all-cause heart failure.
  • Genetic factors may underlie the association between hyperthyroidism and heart failure.