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The genetic association between hyperthyroidism and heart failure: a Mendelian randomization study

Jun Liu1,2, Gujie Wu3, Shuqi Li2

  • 1Department of Health Management, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.

Frontiers in Endocrinology
|April 29, 2024
PubMed

Insights

This study establishes a genetic causal link between hyperthyroidism and an increased risk of heart failure. These findings suggest thyroid dysfunction may directly contribute to heart failure development.

Area of Science:

  • Endocrinology
  • Cardiology
  • Genetics

Background:

  • Hyperthyroidism is an endocrine disorder with diverse causes and symptoms.
  • Heart failure (HF) is a significant clinical condition with high morbidity and mortality.
  • While thyroid dysfunction is linked to heart disease, a causal relationship with HF remains unproven.

Purpose of the Study:

  • To investigate the potential causal relationship between hyperthyroidism and heart failure.
  • To explore the genetic basis of the association between hyperthyroidism and HF.

Main Methods:

  • Utilized two-sample Mendelian randomization (MR) analysis.
  • Employed summary data from a large genetic association study on hyperthyroidism.
  • Analyzed genetically determined all-cause heart failure data from the FinnGen Consortium (218,208 individuals).
  • Applied various statistical methods including inverse variance-weighted, weighted median, and MR-Egger.

Main Results:

  • Inverse variance-weighted analysis revealed a significant causal association between hyperthyroidism and increased risk of all-cause heart failure (OR=1.049, P=0.007).
  • Weighted median analysis corroborated this finding, showing a positive correlation (OR=1.049, P=0.044).
  • No significant horizontal pleiotropy or heterogeneity was detected, and leave-one-out analysis confirmed robustness.

Conclusions:

  • This study provides evidence for a causal relationship between hyperthyroidism and all-cause heart failure.
  • Genetic factors may underlie the association between hyperthyroidism and heart failure.
Abstract

Keywords:
SNPsall-cause heart failureheart failurehyperthyroidismthyroid diseasetwo-sample Mendelian randomization (MR)

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