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SEA-PHAGES and SEA-GENES: Advancing Virology and Science Education.

Danielle M Heller¹, Viknesh Sivanathan¹, David J Asai¹

¹Center for the Advancement of Science Leadership and Culture, Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.

Annual Review of Virology

|April 29, 2024

Summary

The Science Education Alliance (SEA) engages undergraduates in bacteriophage discovery and genomics, fostering scientific persistence and community. This program has supported over 50,000 students in isolating and sequencing thousands of phages.

Keywords:

SEA-GENES SEA-PHAGES bacteriophages course-based research equity in STEMM education

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Area of Science:

Microbiology
Genomics
Education

Background:

Undergraduate research offers significant benefits but faces scalability challenges.
Bacteriophages (phages) present a unique opportunity for large-scale, early-career research due to their diversity.
The Science Education Alliance (SEA) was established to address these challenges by providing a structured research-education community.

Purpose of the Study:

To describe the structure and impact of the Science Education Alliance (SEA) program.
To highlight the success of course-based research experiences in phage discovery, genomics, and genetics.
To demonstrate the program's contribution to scientific discovery and equitable science education.

Main Methods:

The SEA program utilizes two main course-based research projects: SEA-PHAGES and SEA-GENES.
It provides centralized support for students and faculty across various institutions, including community colleges and research universities.
Participants engage in bacteriophage isolation, sequencing, annotation, and gene function characterization.

Main Results:

Since 2008, the SEA has supported over 50,000 undergraduate researchers.
More than 23,000 bacteriophages have been isolated, with over 4,500 fully sequenced and annotated.
Students have functionally characterized hundreds of phage genes, contributing to phage collections used in therapeutic applications.

Conclusions:

Participation in the SEA program significantly promotes student persistence in science education.
The SEA's inclusive model fosters a more equitable scientific community.
The program's large-scale research initiatives have yielded substantial scientific discoveries and practical applications, including phage therapy.