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Published on: September 12, 2019
The Role of HSP90 and TRAP1 Targets on Treatment in Hepatocellular Carcinoma
P K Praveen Kumar1,2, Harini Sundar3, Kamalavarshini Balakrishnan3
1Department of Biotechnology, Sri Venkateswara College of Engineering, Pennalur, Sriperumbudur Tk, Tamil Nadu, 602117, India. praveenpk@svce.ac.in.
Abstract:
Hepatocellular Carcinoma (HCC) is the predominant form of liver cancer and arises due to dysregulation of the cell cycle control machinery. Heat Shock Protein 90 (HSP90) and mitochondrial HSP90, also referred to as TRAP1 are important critical chaperone target receptors for early diagnosis and targeting HCC. Both HSP90 and TRAP1 expression was found to be higher in HCC patients. Hence, the importance of HSP90 and TRAP1 inhibitors mechanism and mitochondrial targeted delivery of those inhibitors function is widely studied. This review also focuses on importance of protein-protein interactions of HSP90 and TRAP1 targets and association of its interacting proteins in various pathways of HCC. To further elucidate the mechanism, systems biology approaches and computational biology approach studies are well explored in the association of inhibition of herbal plant molecules with HSP90 and its mitochondrial type in HCC.
Insights
Heat Shock Protein 90 (HSP90) and its mitochondrial form TRAP1 are key targets for Hepatocellular Carcinoma (HCC) diagnosis and treatment. Inhibitor mechanisms and herbal molecule interactions with HSP90/TRAP1 are crucial for HCC research.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Hepatocellular Carcinoma (HCC) is a major liver cancer type driven by cell cycle dysregulation.
- Heat Shock Protein 90 (HSP90) and its mitochondrial variant TRAP1 are overexpressed in HCC patients.
- HSP90 and TRAP1 serve as critical targets for early HCC diagnosis and therapeutic intervention.
Purpose of the Study:
- To review the mechanisms of HSP90 and TRAP1 inhibitors.
- To explore the role of mitochondrial-targeted delivery of these inhibitors.
- To examine protein-protein interactions involving HSP90 and TRAP1 in HCC pathways.
Main Methods:
- Literature review focusing on HSP90 and TRAP1 in HCC.
- Analysis of studies on inhibitor mechanisms and targeted delivery.
- Exploration of systems biology and computational approaches.
Main Results:
- Elevated HSP90 and TRAP1 expression correlates with HCC.
- HSP90 and TRAP1 inhibitors show therapeutic potential.
- Protein-protein interactions and herbal molecule inhibition are key research areas.
Conclusions:
- HSP90 and TRAP1 are significant biomarkers and therapeutic targets for HCC.
- Targeted delivery and understanding molecular interactions are vital for HCC treatment strategies.
- Herbal compounds offer a promising avenue for inhibiting HSP90/TRAP1 in HCC.
