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An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging
Jaewon Kim1, Jiyoung Yoo1, Byungkook Kim1
1Department of Chemistry, Korea University, Seoul, 02841, Korea. jongskim@korea.ac.kr.
Chemical Communications (Cambridge, England)
|April 30, 2024
Abstract:
An AIE-based fluorescent probe was designed to evaluate peroxynitrite levels in complex biological samples. The newly synthesized hydrazone-conjugated probe fluoresces strongly in the presence of peroxynitrite. Clinically, the peroxynitrite levels can be measured in human serum and cellular mitochondria with an LOD of 6.5 nM by fluorescence imaging in vitro.
