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Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
Published on: September 13, 2014
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Does depressurization of the portal vein before liver transplantation affect the recurrence of HCC? A nested
Guo Wei1, Yong Zhao1, Shifeng Feng1
1Department of General Surgery, Public health clinical center of chengdu, Chengdu, Sichuan Province, China.
BMC Cancer
|May 3, 2024
Summary
Depressurization of the portal vein (DPV) before liver transplantation (LT) may reduce hepatocellular carcinoma (HCC) recurrence in early stages. DPV treatment prior to HCC occurrence shows promise in improving outcomes after LT.
Area of Science:
- Hepatobiliary Surgery
- Transplantation Medicine
- Oncology
Background:
- Portal hypertension (PHT) is linked to hepatocellular carcinoma (HCC) development.
- The impact of PHT management before liver transplantation (LT) on HCC recurrence remains unclear.
Purpose of the Study:
- To investigate whether portal vein depressurization (DPV) before LT influences HCC recurrence.
- To analyze the effect of DPV timing relative to HCC diagnosis on post-LT outcomes.
Main Methods:
- A nested case-control study matched 110 patients who underwent DPV operations before LT with 330 preoperative non-DPV patients.
- Subgroup analysis examined DPV timing: before or after HCC occurrence.
Main Results:
- DPV group had higher rates of acute kidney injury and intra-abdominal bleeding post-LT.
- Overall 5-year survival rates were similar between DPV and non-DPV groups (83.4% vs. 82.7%).
- DPV before HCC (TNM I-II stages) was associated with lower HCC recurrence (4.7% vs. 16.8%) and higher tumor-free survival (88.9% vs. 74.4%) compared to other groups.
Conclusions:
- DPV treatment before HCC occurrence can significantly reduce HCC recurrence after early LT (TNM I-II stages).
- DPV prior to LT is beneficial for reducing early HCC recurrence.
