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Microbiome dynamics in immune checkpoint blockade
Chae Won Kim1, Hyun-Jin Kim1, Heung Kyu Lee2
1Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea; Life Science Institute, KAIST, Daejeon 34141, Republic of Korea.
Trends in Endocrinology and Metabolism: TEM
|May 5, 2024
Summary
The gut and tumor microbiome significantly impact cancer immunotherapy effectiveness. Understanding these microbial communities is crucial for improving immune checkpoint blockade (ICB) treatment responses in patients.
Area of Science:
- Oncology
- Immunology
- Microbiology
Background:
- Immune checkpoint blockade (ICB) is a key cancer immunotherapy.
- Patient responses to ICB vary significantly across cancer types and individuals.
- The microbiome is increasingly recognized as a modulator of ICB efficacy.
Purpose of the Study:
- To review current research on the microbiome's influence on ICB.
- To highlight the roles of both intestinal and intratumoral microbiomes.
- To discuss advancements in studying the microbiome's impact on cancer treatment.
Main Methods:
- Analysis of clinical trials involving ICB and microbiome data.
- Review of observational studies in human cancer patients.
- Examination of findings from preclinical animal models.
Main Results:
- The composition of the intestinal microbiome affects patient response to ICB.
- The presence and type of intratumoral microbiome also influence ICB efficacy.
- Methodological progress aids in understanding these complex interactions.
Conclusions:
- The microbiome is a critical factor in determining ICB success.
- Targeting the microbiome may enhance cancer immunotherapy outcomes.
- Further research integrating microbiome analysis is essential for personalized ICB therapy.
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