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Updated: Jun 27, 2025
Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
Published on: June 21, 2016
Dataset on cardiac structural and functional parameters in TMAO-challenged mouse
Yingyu Wang1,2, Chenchen Qin3, Shiyi Tian3
1Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Abstract:
Trimethylamine-N-oxide (TMAO) is a gut-derived metabolite formed from dietary choline and l-carnitine, known to impede cholesterol metabolism and is implicated in the pathogenesis of thrombosis and atherosclerosis, contributing to the etiology of cardiovascular diseases. We present a dataset derived from an experimental study designed to elucidate the cardiotoxic effects of TMAO. This dataset encompasses echocardiographic assessments from two cohorts of mice: one subjected to a 6-week regimen of 20 mg/kg/day TMAO injections (n = 16) and a control group (n = 18). Each subject's echocardiographic dataset comprises six high-resolution TIFF images, capturing both B-type and M-mode views in standard echocardiographic planes, along with two additional M-mode images enriched with analysed cardiac functional data. Complementing these images, a CSV-formatted report details critical cardiac parameters, including heart rate, ejection fraction, and fractional shortening, among others. In a novel approach to enhance data integrity and permit tailored analyses, we provide the original output files from the echocardiography apparatus, which researchers can reprocess using dedicated analysis software. This dataset is anticipated to be instrumental in advancing our understanding of the mechanistic links between TMAO exposure and cardiac dysfunction.
Insights
Trimethylamine-N-oxide (TMAO) exposure in mice impairs cardiac function, impacting cholesterol metabolism and cardiovascular health. This study provides a dataset for further research into TMAO
Area of Science:
- Cardiovascular Science
- Metabolomics
- Toxicology
Background:
- Trimethylamine-N-oxide (TMAO) is a gut-derived metabolite linked to cardiovascular diseases.
- TMAO impedes cholesterol metabolism and is implicated in thrombosis and atherosclerosis.
- Understanding TMAO's cardiotoxic effects is crucial for cardiovascular health research.
Purpose of the Study:
- To present a comprehensive dataset on the cardiotoxic effects of TMAO exposure.
- To facilitate research into the mechanistic links between TMAO and cardiac dysfunction.
- To provide raw and analyzed echocardiographic data for advanced analysis.
Main Methods:
- Echocardiographic assessments were performed on two cohorts of mice.
- One cohort received daily TMAO injections for six weeks; a control group did not.
- Data includes high-resolution B-mode and M-mode images, analyzed cardiac functional data, and raw output files.
Main Results:
- The dataset captures cardiac functional parameters such as heart rate, ejection fraction, and fractional shortening.
- Includes raw echocardiography output files for reprocessing and detailed analysis.
- Provides a foundation for investigating TMAO's impact on cardiac mechanics.
Conclusions:
- This dataset enables in-depth investigation of TMAO's cardiotoxic mechanisms.
- Facilitates research on TMAO's role in cardiovascular disease etiology.
- Supports the development of targeted interventions for TMAO-related cardiac dysfunction.
