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Updated: Jun 27, 2025
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Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
Published on: June 21, 2016
18.2K
Dataset on cardiac structural and functional parameters in TMAO-challenged mouse
Yingyu Wang1,2, Chenchen Qin3, Shiyi Tian3
1Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Data in Brief
|May 7, 2024
Summary
Trimethylamine-N-oxide (TMAO) exposure in mice impairs cardiac function, impacting cholesterol metabolism and cardiovascular health. This study provides a dataset for further research into TMAO
Area of Science:
- Cardiovascular Science
- Metabolomics
- Toxicology
Background:
- Trimethylamine-N-oxide (TMAO) is a gut-derived metabolite linked to cardiovascular diseases.
- TMAO impedes cholesterol metabolism and is implicated in thrombosis and atherosclerosis.
- Understanding TMAO's cardiotoxic effects is crucial for cardiovascular health research.
Purpose of the Study:
- To present a comprehensive dataset on the cardiotoxic effects of TMAO exposure.
- To facilitate research into the mechanistic links between TMAO and cardiac dysfunction.
- To provide raw and analyzed echocardiographic data for advanced analysis.
Main Methods:
- Echocardiographic assessments were performed on two cohorts of mice.
- One cohort received daily TMAO injections for six weeks; a control group did not.
- Data includes high-resolution B-mode and M-mode images, analyzed cardiac functional data, and raw output files.
Main Results:
- The dataset captures cardiac functional parameters such as heart rate, ejection fraction, and fractional shortening.
- Includes raw echocardiography output files for reprocessing and detailed analysis.
- Provides a foundation for investigating TMAO's impact on cardiac mechanics.
Conclusions:
- This dataset enables in-depth investigation of TMAO's cardiotoxic mechanisms.
- Facilitates research on TMAO's role in cardiovascular disease etiology.
- Supports the development of targeted interventions for TMAO-related cardiac dysfunction.
