Self-Assembled Origami Neural Probes for Scalable, Multifunctional, Three-Dimensional Neural Interface.

Area of Science:

• Neuroscience
• Biomedical Engineering
• Materials Science

Background:

• Flexible intracortical neural probes offer improved longevity and reduced tissue response for high-resolution neural recordings.
• Conventional fabrication methods face challenges in scaling recording sites, integrating diverse sensing modalities, and creating 3D electrode arrays.

Conclusions:

• The modular self-assembly technology enables scalable, multifunctional, and 3D-configurable neural probes.
• Origami neural probes represent a flexible and customizable solution for advanced neural recording and modulation.
• This approach significantly advances the capabilities for in vivo neuroscience research.