Jove
Visualize
Contact Us

Related Concept Videos

Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.4K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.4K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stem-like memory-T maintenance and differentiation into tissue-resident T cells sustain chronic graft-versus-host disease in mice.

Nature communications·2026
Same author

Species-specific serine metabolism differentially controls natural killer cell functions.

Nature metabolism·2025
Same author

Enterotoxigenic Escherichia coli heat-labile enterotoxin induces cell death and disrupts effector functions in porcine monocytes.

Veterinary research·2025
Same author

Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.

Nature metabolism·2025
Same author

Enterotoxigenic <i>Escherichia coli</i> heat labile enterotoxin affects neutrophil effector functions via cAMP/PKA/ERK signaling.

Gut microbes·2024
Same author

Author Correction: MEF2C regulates NK cell effector functions through control of lipid metabolism.

Nature immunology·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 27, 2025

Time-lapse Imaging of Mouse Macrophage Chemotaxis
09:33

Time-lapse Imaging of Mouse Macrophage Chemotaxis

Published on: April 2, 2020

11.7K

Send it, receive it, quick erase it: A mouse model to decipher chemokine communication.

Leen Hermans1, Timothy E O'Sullivan1,2

  • 1Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.

The Journal of Experimental Medicine
|May 7, 2024
PubMed
Summary

Researchers developed novel dual fluorescence reporter mice to precisely identify cells that produce or sense chemokines. This breakthrough enables accurate tracking of cellular responses to chemokines in both laboratory and living organism settings.

More Related Videos

An Ectopic Chemokine Expression Model for Testing Macrophage Recruitment In Vivo
10:02

An Ectopic Chemokine Expression Model for Testing Macrophage Recruitment In Vivo

Published on: September 25, 2019

5.3K
Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
09:40

Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum

Published on: September 20, 2011

18.0K

Related Experiment Videos

Last Updated: Jun 27, 2025

Time-lapse Imaging of Mouse Macrophage Chemotaxis
09:33

Time-lapse Imaging of Mouse Macrophage Chemotaxis

Published on: April 2, 2020

11.7K
An Ectopic Chemokine Expression Model for Testing Macrophage Recruitment In Vivo
10:02

An Ectopic Chemokine Expression Model for Testing Macrophage Recruitment In Vivo

Published on: September 25, 2019

5.3K
Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
09:40

Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum

Published on: September 20, 2011

18.0K

Area of Science:

  • Immunology
  • Cell Biology
  • Genetics

Background:

  • Accurate identification of chemokine-responsive cells is crucial for understanding immune responses.
  • Existing methods for tracking chemokine interactions in vivo are limited.
  • Chemokines play vital roles in directing cell migration and immune cell function.

Purpose of the Study:

  • To develop a novel method for precisely identifying cells that respond to chemokines in vivo.
  • To establish a tool for distinguishing between chemokine production and sensing by specific cell populations.
  • To advance the study of cellular communication in immunological contexts.

Main Methods:

  • Generation of a novel class of dual fluorescence reporter mice.
  • In vitro validation of reporter system for chemokine production and sensing.
  • In vivo application to track chemokine-responsive cells in a living organism.

Main Results:

  • The dual fluorescence reporter mice successfully identified specific cell populations responding to chemokines.
  • The system differentiated between cells producing and cells sensing chemokines.
  • Demonstrated utility in tracking chemokine-mediated cellular responses in vivo.

Conclusions:

  • Dual fluorescence reporter mice offer a precise method to determine chemokine responsiveness in vivo.
  • This technology facilitates detailed analysis of chemokine-driven cellular behavior.
  • The developed system represents a significant advancement for immunological research.