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Lighting ATR/Chk1 by mesoscale TopBP1 condensates

Yan Qin1, Lei Shi1

  • 1Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin 300070, China.

Trends in Cell Biology
|May 7, 2024
PubMed
Summary

Biomolecular condensation is key in cell signaling. Egger et al. reveal how topoisomerase IIβ binding protein 1 (TopBP1) condensates facilitate Chk1 activation by ATR, advancing our understanding of DNA damage response.

Keywords:
ATRChk1TopBP1biomolecular condensate

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