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Updated: Jun 26, 2025

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
BF3·Et2O-assisted synthesis of sulfinylated spiro[5.5]trienones from biaryl ynones
Barnali Roy1, Puspendu Kuila1, Sangam Jha1
1Department of Chemistry, NIT Rourkela, Odisha, 769008, India. barnaliroy090@gmail.com.
Abstract:
Sulfinyls are valuable structural moieties used for developing synthetically new pharmaceuticals and agrochemicals. Herein, we disclose a straightforward synthesis of sulfinylated spiro[5.5]trienones proceeding via an unprecedented BF3·Et2O-promoted spirocyclization of biaryl ynones. The availability of relatively inexpensive BF3·Et2O to carry out transformations on a bulk scale along with its further application towards the synthesis of dibenzocyclohepten-5-ones delivers a unique opportunity to deploy it in various synthetic directions.
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