Related Experiment Video
Updated: Jun 26, 2025
12:59
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
12.6K
E-PROOF: E-intervention for protein intake and resistance training to optimize function: A study protocol
Jessica L Krok-Schoen1, Zachary L Chaplow2, Cara Chase1
1School of Health and Rehabilitation Sciences, College of Medicine, The Ohio State University, Columbus, OH, United States of America.
Plos One
|May 8, 2024
Summary
This study tests an online program combining nutrition and resistance training for older cancer survivors to improve physical function and quality of life. The E-PROOF intervention shows promise for enhancing health behaviors and outcomes in this population.
Area of Science:
- Gerontology
- Oncology
- Exercise Physiology
Background:
- Older cancer survivors (≥65 years) face a 2-5x higher risk of physical function impairment compared to peers.
- Physical function decline significantly impacts quality of life and independence in this demographic.
- Targeted interventions are crucial to mitigate long-term health consequences of cancer and its treatment.
Purpose of the Study:
- To evaluate the feasibility, acceptability, and preliminary efficacy of the E-PROOF (E-intervention for Protein Intake and Resistance Training to Optimize Function) study.
- To assess the impact of a 12-week online, tailored nutritional and resistance training intervention on physical function.
- To examine effects on muscle strength, health-related quality of life (HRQoL), self-efficacy, and weight management in older cancer survivors.
Main Methods:
- A 12-week randomized controlled trial involving 70 older cancer survivors.
- Experimental group received remote behavioral counseling and tailored education; control group received general survivorship education.
- Intervention effects measured on physical function, muscle strength, HRQoL, self-efficacy, weight, and waist circumference, with a 3-month follow-up.
Main Results:
- The study aims to provide preliminary data on the intervention's efficacy in improving key physical and health outcomes.
- Analysis will compare changes between the experimental and control groups over the 12-week intervention period and at follow-up.
- Feasibility and acceptability data will inform future, larger-scale trials.
Conclusions:
- This is the first synchronous, online protein-focused diet and resistance training intervention for older cancer survivors.
- The study promotes independent health behaviors and provides foundational knowledge for scalable online interventions.
- Findings are expected to advance strategies for improving health outcomes in aging cancer survivors.
Related Concept Videos
01:28Proteins: Dietary Sources and Requirements
431
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
431
01:27Exercise and Muscle Performance
1.4K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.4K
01:21Overview of Protein Metabolism
1.1K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.1K
02:26Protein Networks
3.9K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K
02:04Protein-protein Interfaces
12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K